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IN THE UNWED STATES PATENT AND TRADEMIK OFFICE 




In re the Application of: D. Ward et 
Serial No.: 09/335,956 
Filed: June 18, 1999 



For: DELINEATION OF INDIVIDUAL HUMAN 
CHROMOSOMES IN METAPHASE AND 
INTERPHASE CELLS BY IN SITU SUPPRESSION 
HYBRIDIZATION 

Attorney Docket No: IGI-Q01CN3 



Group Art Unit: 
Examiner: Forman, B 




Assistant Commissioner for Patents 
Washington, D.C.. 20231 



Certificate of First Class Mailing 
I hereby certify that this correspondence is being deposited with the United States Postal Service as first class mail 
in an envelope addressed to: Assistant Commissioner for Patents, Washington, D.C. 20231, on the date set forth 
below. 

K 




Date of Signaturaand of Mail Deposit 




e M. DiGio 
g. No. 41,710 
Attorney for Applicants 




Dear Sir: 



RESPONSE 



Pursuant to a telephonic interview with the Examiner regarding the above- 
identified application, Applicants submit herewith the following documents: 

( 1 ) a copy of the substitute specification previously filed on June 18,1 999; 

(2) a red-lined copy of the substitute specification previously filed on June 18, 
1999; and 

(3) copies of the amendments to the original specification which were filed in the 
parent applications on February 14, 1992, January 23, 1995, and April 29, 1996 and which have 
been incorporated into the substitute specification submitted herewith. 



_ Art Unit: 1655 

Serial No.: 09/335,95^ " 2 " • 



REMARKS 

a ril 1 9 2000 the Examiner requested 

m at,he foUowingdocumentsbe submitted: a subs ,^ ^cation 

whic h were fled in the parent ^— " ^ specificatio , 

1QOS and April 29, 
In particular, the red-lined copy o 

ame " dme " K , ,mes6-,l theadditio-ofteiatedappiicationda^teiiminary 
At page 1, lines b n," 

fnrm filed June 18, 

At pages 3-9, the amendment ol the tig 

01 1995V 

(WW-, — ent, filed anuar, , • 
At pages 9-10, the amendment of Ftgure 

ffled February 14, 1992); ^ ^ page 27 , , ine 2 4; page 

At page 21, .ine 29; page 23, hne 3 . M ^ ^ ^ ^ ^ J4; 

28 , lines 2-3; page 29, lines 26-27; page 30 .me 9 P g 
page 36, line 6; page 36, ,inel6;*e amendment ofthefigu 

ffled April 29, 1996); and Amendment> flle d 

At pages 44-53, the addmon of Example I. 

February 14, 1992). 

No new matter has been added. 



A Art Unit: 1655 

Serial No.: 09/335,956^ " 3 " • 

, * m 19 2000 Applicants note that claims 1-18, as reproduced 
Further as discussed on April 19, 200U, a PP 

Respectfully submitted, 
LAHIVE & COCKFIELD, LLP 



m 



28 State Street 
Boston, MA 02109 
Tel. (617) 227-7400 



Dated: 



06 




RegistrationNo. 41, 
Attorney for Applicants